The A27 was closed after a man died in a crash this morning (Saturday 30 November).
National Highways said that the A27 was open eastbound but remained closed westbound, between the A29 and A285.
Work to clear the crash scene was continuing, the agency said.
Sussex Police said: “Just after midnight today officers responded to a road traffic collision on the A27, on the westbound carriageway in Fontwell.
“Three vehicles were involved in the serious collision and, sadly, a 38-year-old man from Rustington was confirmed deceased at the scene.
“His next of kin have been informed.
“The drivers of the other two vehicles and three passengers sustained minor injuries and were assessed by paramedics.
“A diversion remains in place around Fontwell roundabout and we ask those travelling to avoid the area at this time.
“If you witnessed the collision or have footage of the incident, we ask you contact police.
“You can do this by emailing collision.appeal@sussex.police.uk or by calling 101, quoting Operation Vizsla.”